Assay Detail
Binding
CHEMBL673081
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In vitro binding affinity at human cloned Dopamine receptor D2L expressed in Sf9 cell membranes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.15 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.07 |
| CHEMBL148353 | — | — | 1 | 6.87 |
| CHEMBL148694 | — | — | 1 | 6.83 |
| CHEMBL358657 | — | — | 1 | 6.74 |
| CHEMBL342536 | — | — | 1 | 6.74 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.43 |
| CHEMBL148559 | — | — | 1 | 6.24 |
| CHEMBL422310 | — | — | 1 | 6.20 |
| CHEMBL436274 | — | — | 1 | 6.05 |
| CHEMBL356149 | — | — | 1 | 5.96 |
| CHEMBL63576 | — | — | 1 | 5.65 |
| CHEMBL347959 | — | — | 1 | 5.59 |
| CHEMBL63329 | — | — | 1 | 5.23 |
| CHEMBL146856 | — | — | 1 | 5.00 |
| CHEMBL148042 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL148353 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL148694 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL358657 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL342536 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL42 | CLOZAPINE | Ki | = | 372.0 | nM | 6.43 |
| CHEMBL148559 | — | Ki | = | 571.0 | nM | 6.24 |
| CHEMBL422310 | — | Ki | = | 635.0 | nM | 6.20 |
| CHEMBL436274 | — | Ki | = | 892.0 | nM | 6.05 |
| CHEMBL356149 | — | Ki | = | 1099.0 | nM | 5.96 |
| CHEMBL63576 | — | Ki | = | 2235.0 | nM | 5.65 |
| CHEMBL347959 | — | Ki | = | 2596.0 | nM | 5.59 |
| CHEMBL63329 | — | Ki | = | 5940.0 | nM | 5.23 |
| CHEMBL146856 | — | Ki | = | 9943.0 | nM | 5.00 |
| CHEMBL148042 | — | Ki | = | 19117.0 | nM | 4.72 |