Assay Detail
Binding
CHEMBL673095
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In vitro binding affinity towards Dopamine receptor D2 by using [3H]U-86170 as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.18 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021538 | — | — | 1 | 8.06 |
| CHEMBL28437 | — | — | 1 | 7.21 |
| CHEMBL2021539 | — | — | 1 | 7.16 |
| CHEMBL26998 | — | — | 1 | 7.05 |
| CHEMBL28313 | — | — | 1 | 6.97 |
| CHEMBL2021524 | — | — | 1 | 6.65 |
| CHEMBL2021525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021538 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL28437 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL2021539 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL26998 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL28313 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL2021524 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL2021525 | — | Ki | > | 3800.0 | nM | - |