Assay Detail
Binding
CHEMBL673112
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Potency of inhibition against human leukocyte elastase (HLE) expressed as an apparent binding constant
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 10.30 | 10.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163414 | — | — | 1 | 10.96 |
| CHEMBL348965 | — | — | 1 | 10.96 |
| CHEMBL114992 | — | — | 1 | 10.89 |
| CHEMBL164352 | — | — | 1 | 10.89 |
| CHEMBL435666 | — | — | 1 | 10.85 |
| CHEMBL162863 | — | — | 1 | 9.70 |
| CHEMBL50803 | — | — | 1 | 7.82 |
| CHEMBL162877 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163414 | — | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL348965 | — | Ki | = | 0.011 | nM | 10.96 |
| CHEMBL114992 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL164352 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL435666 | — | Ki | = | 0.014 | nM | 10.85 |
| CHEMBL162863 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL50803 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL162877 | — | Ki | = | 0.008 | nM | - |