Assay Detail
Binding
CHEMBL673116
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Binding affinity at Dopamine receptor D3 expressed in CHO cells by [125I]iodosulpiride displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Fused aminotetralins: novel antagonists with high selectivity for the dopamine D3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.49 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99198 | — | — | 1 | 9.00 |
| CHEMBL319116 | — | — | 1 | 8.70 |
| CHEMBL99876 | — | — | 1 | 8.30 |
| CHEMBL318925 | — | — | 1 | 8.20 |
| CHEMBL2111591 | — | — | 1 | 8.10 |
| CHEMBL95759 | — | — | 1 | 8.10 |
| CHEMBL2111592 | — | — | 1 | 8.00 |
| CHEMBL97856 | — | — | 1 | 7.90 |
| CHEMBL95743 | — | — | 1 | 7.80 |
| CHEMBL97118 | — | — | 1 | 7.80 |
| CHEMBL98452 | — | — | 1 | 7.80 |
| CHEMBL329702 | — | — | 1 | 7.30 |
| CHEMBL97107 | — | — | 1 | 7.30 |
| CHEMBL97440 | — | — | 1 | 6.70 |
| CHEMBL317996 | — | — | 1 | 6.60 |
| CHEMBL97840 | — | — | 1 | 6.60 |
| CHEMBL419706 | — | — | 1 | 6.20 |
| CHEMBL97149 | — | — | 1 | 6.10 |
| CHEMBL319355 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99198 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL319116 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL99876 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL318925 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL2111591 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL95759 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL2111592 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL97856 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL95743 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL97118 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL98452 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL329702 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL97107 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL97440 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL317996 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL97840 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL419706 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL97149 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL319355 | — | Ki | = | 1258.93 | nM | 5.90 |