Assay Detail
Binding
CHEMBL673229
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Binding affinity towards human Endothelin B receptor by measuring its ability to displace [125I]ET-3 from CHO cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.24 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302564 | — | — | 1 | 7.69 |
| CHEMBL305980 | — | — | 1 | 7.61 |
| CHEMBL25344 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302564 | — | Ki | = | 20.4 | nM | 7.69 |
| CHEMBL305980 | — | Ki | = | 24.5 | nM | 7.61 |
| CHEMBL25344 | — | Ki | = | 371.0 | nM | 6.43 |