Assay Detail
Binding
CHEMBL673233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]ET1 binding to cloned human ET-B receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.37 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8823 | SB-209670 | — | 1 | 7.83 |
| CHEMBL41087 | — | — | 1 | 6.32 |
| CHEMBL38537 | — | — | 1 | 6.12 |
| CHEMBL39142 | — | — | 1 | 5.98 |
| CHEMBL290026 | — | — | 1 | 5.61 |
| CHEMBL39171 | — | — | 1 | - |
| CHEMBL39057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8823 | SB-209670 | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL41087 | — | Ki | = | 483.0 | nM | 6.32 |
| CHEMBL38537 | — | Ki | = | 757.0 | nM | 6.12 |
| CHEMBL39142 | — | Ki | = | 1044.0 | nM | 5.98 |
| CHEMBL290026 | — | Ki | = | 2443.0 | nM | 5.61 |
| CHEMBL39171 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL39057 | — | Ki | > | 30000.0 | nM | - |