Assay Detail
Binding
CHEMBL673235
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Inhibitory activity against human Endothelin B receptor in chinese hamster ovary cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.26 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8978 | L-754142 | — | 1 | 8.27 |
| CHEMBL8823 | SB-209670 | — | 1 | 7.83 |
| CHEMBL8981 | PD-156707 | — | 1 | 6.86 |
| CHEMBL8923 | — | — | 1 | 6.86 |
| CHEMBL428661 | — | — | 1 | 6.46 |
| CHEMBL267458 | BMS-182874 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8978 | L-754142 | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL8823 | SB-209670 | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL8981 | PD-156707 | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL8923 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL428661 | — | Ki | = | 343.0 | nM | 6.46 |
| CHEMBL267458 | BMS-182874 | Ki | > | 50000.0 | nM | - |