Assay Detail
Binding
CHEMBL673248
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Tested for binding affinity towards human D2L receptor using [3H]spiperone as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.15 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.30 |
| CHEMBL335545 | CI-1007 | — | 1 | 7.59 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL335545 | CI-1007 | Ki | = | 25.5 | nM | 7.59 |
| CHEMBL53 | APOMORPHINE | Ki | = | 28.0 | nM | 7.55 |