Assay Detail
Binding
CHEMBL673251
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Affinity was evaluated as inhibition constant for dopamine D-4 receptor
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.57 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415300 | ISOCLOZAPINE | — | 1 | 7.80 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.68 |
| CHEMBL266723 | — | — | 1 | 6.92 |
| CHEMBL94067 | — | — | 3 | 6.82 |
| CHEMBL90654 | — | — | 1 | 6.72 |
| CHEMBL91350 | — | — | 1 | 6.50 |
| CHEMBL327713 | — | — | 1 | 6.48 |
| CHEMBL89719 | — | — | 1 | 6.40 |
| CHEMBL73538 | — | — | 1 | 6.38 |
| CHEMBL269396 | — | — | 1 | 6.00 |
| CHEMBL7430 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415300 | ISOCLOZAPINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL42 | CLOZAPINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL266723 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL94067 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL90654 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL94067 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL91350 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL327713 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL89719 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL73538 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL269396 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL94067 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL7430 | — | Ki | = | 2700.0 | nM | 5.57 |