Assay Detail
Binding
CHEMBL673258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]WIN-35428 binding to the dopamine transporter in cynomolgus (macaca fascicularis) monkey caudate putamen.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.62 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88915 | — | — | 1 | 8.92 |
| CHEMBL84680 | — | — | 1 | 8.54 |
| CHEMBL89469 | — | — | 1 | 6.39 |
| CHEMBL101986 | — | — | 1 | 6.17 |
| CHEMBL318592 | — | — | 1 | 6.10 |
| CHEMBL100010 | — | — | 1 | 5.42 |
| CHEMBL103138 | — | — | 1 | 4.80 |
| CHEMBL103831 | — | — | 1 | - |
| CHEMBL323348 | DIMETHYL PHTHALATE | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88915 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL84680 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL89469 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL101986 | — | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL318592 | — | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL100010 | — | IC50 | = | 3816.0 | nM | 5.42 |
| CHEMBL103138 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL103831 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL323348 | DIMETHYL PHTHALATE | IC50 | > | 100000.0 | nM | - |