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Assay Detail

CHEMBL673295

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Functional
Inhibition of Ehrlich ascites cell respiration
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type Ehrlich
Confidence 1 — Organism
Curated By Expert

Target

Ehrlich (CHEMBL614641)
Type CELL-LINE
Organism Mus musculus

Publication

4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions.
Coats EA, Shah KJ, Milstein SR, Genther CS, Nene DM, Roesener J, Schmidt J, Pleiss M, Wagner E, Baker JK.
J Med Chem (1982) 25 : 57 -63
PubMed 7086823 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.32 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL157654 1 4.82
CHEMBL157710 1 4.41
CHEMBL156108 1 4.37
CHEMBL160792 1 4.27
CHEMBL155958 1 4.07
CHEMBL434275 1 4.00
CHEMBL139402 1 -
CHEMBL138027 1 -
CHEMBL160456 1 -
CHEMBL141025 1 -
CHEMBL156384 1 -
CHEMBL343799 1 -
CHEMBL158890 1 -
CHEMBL139244 1 -
CHEMBL138298 1 -
CHEMBL344461 1 -
CHEMBL347711 1 -
CHEMBL139078 1 -
CHEMBL345688 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL157654 IC50 = 15135.61 nM 4.82
CHEMBL157710 IC50 = 38904.51 nM 4.41
CHEMBL156108 IC50 = 42657.95 nM 4.37
CHEMBL160792 IC50 = 53703.18 nM 4.27
CHEMBL155958 IC50 = 85113.8 nM 4.07
CHEMBL434275 IC50 = 100000.0 nM 4.00
CHEMBL139402 IC50 = 3388441.56 nM -
CHEMBL138027 IC50 = 912010.84 nM -
CHEMBL160456 IC50 = 5754399.37 nM -
CHEMBL141025 IC50 = 794328.23 nM -
CHEMBL156384 IC50 = 165958.69 nM -
CHEMBL343799 IC50 = 1778279.41 nM -
CHEMBL158890 IC50 = 1047128.55 nM -
CHEMBL139244 IC50 = 575439.94 nM -
CHEMBL138298 IC50 = 467735.14 nM -
CHEMBL344461 IC50 = 144543.98 nM -
CHEMBL347711 IC50 = 524807.46 nM -
CHEMBL139078 IC50 = 5754399.37 nM -
CHEMBL345688 IC50 = 501187.23 nM -