Assay Detail
Binding
CHEMBL673417
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Inhibition of [3H]WIN-35428 binding to dopamine transporter (DAT) of cynomolgus monkey caudate-putamen
14
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca fascicularis |
| Tissue | Caudate-putamen |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL5032) ↗| Type | SINGLE PROTEIN |
| Organism | Macaca fascicularis |
Publication
Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.41 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87031 | — | — | 2 | 9.42 |
| CHEMBL169471 | — | — | 1 | 9.15 |
| CHEMBL88915 | — | — | 1 | 8.92 |
| CHEMBL316342 | — | — | 4 | 8.64 |
| CHEMBL169429 | — | — | 2 | 8.38 |
| CHEMBL322923 | — | — | 1 | 8.15 |
| CHEMBL100941 | — | — | 2 | 8.02 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87031 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL169471 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL87031 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL88915 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL316342 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL316342 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL316342 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL316342 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL169429 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL322923 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL100941 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL169429 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL100941 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL370805 | COCAINE | IC50 | = | 95.6 | nM | 7.02 |