Assay Detail
Binding
CHEMBL673443
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Binding affinity against dopamine receptor D3 in HEK 293 cells using [3H]spiperone radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.69 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93868 | — | — | 1 | 7.64 |
| CHEMBL126340 | — | — | 1 | 7.18 |
| CHEMBL76237 | — | — | 1 | 7.10 |
| CHEMBL317535 | — | — | 1 | 6.96 |
| CHEMBL92139 | — | — | 1 | 6.52 |
| CHEMBL125745 | — | — | 1 | 6.03 |
| CHEMBL127411 | — | — | 1 | 5.43 |
| CHEMBL263700 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93868 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL126340 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL76237 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL317535 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL92139 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL125745 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL127411 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL263700 | — | Ki | > | 3500.0 | nM | - |