Assay Detail
Binding
CHEMBL673444
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Binding affinity against dopamine receptor D3 using radioligand [3H]spiperone
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.17 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.02 |
| CHEMBL432059 | — | — | 1 | 5.31 |
| CHEMBL7927 | FAUC 113 | — | 1 | 5.30 |
| CHEMBL310843 | — | — | 1 | 5.28 |
| CHEMBL88937 | — | — | 1 | 5.00 |
| CHEMBL90374 | — | — | 1 | 4.92 |
| CHEMBL91362 | — | — | 1 | 4.92 |
| CHEMBL328925 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL432059 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL7927 | FAUC 113 | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL310843 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL88937 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL90374 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL91362 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL328925 | — | Ki | = | 23000.0 | nM | 4.64 |