Assay Detail
Binding
CHEMBL673445
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Binding affinity against human Dopamine receptor D3 in CHO-K1 cells using [3H]spiperone as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.41 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431367 | ROXINDOLE | 2.0 | 1 | 9.40 |
| CHEMBL109101 | — | — | 1 | 8.59 |
| CHEMBL110489 | — | — | 1 | 8.19 |
| CHEMBL109063 | — | — | 1 | 8.15 |
| CHEMBL108463 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431367 | ROXINDOLE | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL109101 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL110489 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL109063 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL108463 | — | Ki | = | 20.0 | nM | 7.70 |