Assay Detail
Binding
CHEMBL673446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at dopamine receptor D3
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.97 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419505 | — | — | 1 | 9.05 |
| CHEMBL301242 | — | — | 1 | 8.85 |
| CHEMBL110411 | — | — | 1 | 8.85 |
| CHEMBL69717 | — | — | 1 | 8.39 |
| CHEMBL306672 | — | — | 1 | 8.11 |
| CHEMBL2308105 | — | — | 1 | 7.86 |
| CHEMBL307800 | — | — | 1 | 7.72 |
| CHEMBL68860 | — | — | 1 | 7.62 |
| CHEMBL68720 | — | — | 1 | 7.55 |
| CHEMBL309118 | — | — | 1 | 7.44 |
| CHEMBL109299 | — | — | 1 | 7.27 |
| CHEMBL12375 | — | — | 1 | 7.20 |
| CHEMBL106660 | — | — | 1 | 7.14 |
| CHEMBL67750 | — | — | 1 | 6.96 |
| CHEMBL12004 | — | — | 1 | 6.95 |
| CHEMBL417249 | — | — | 1 | 6.89 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 6.84 |
| CHEMBL108527 | — | — | 1 | 6.77 |
| CHEMBL320114 | — | — | 1 | 6.71 |
| CHEMBL323997 | — | — | 1 | 6.67 |
| CHEMBL3084884 | — | — | 1 | 6.66 |
| CHEMBL267562 | — | — | 1 | 6.56 |
| CHEMBL302796 | — | — | 1 | 6.47 |
| CHEMBL322179 | — | — | 1 | 6.37 |
| CHEMBL110349 | — | — | 1 | 6.37 |
| CHEMBL108637 | — | — | 1 | 5.84 |
| CHEMBL324896 | — | — | 1 | 5.62 |
| CHEMBL110435 | — | — | 1 | 5.60 |
| CHEMBL110120 | — | — | 1 | 5.40 |
| CHEMBL310310 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419505 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL301242 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL110411 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL69717 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL306672 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL2308105 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL307800 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL68860 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL68720 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL309118 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL109299 | — | Ki | = | 53.2 | nM | 7.27 |
| CHEMBL12375 | — | Ki | = | 63.3 | nM | 7.20 |
| CHEMBL106660 | — | Ki | = | 72.7 | nM | 7.14 |
| CHEMBL67750 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL12004 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL417249 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL108527 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL320114 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL323997 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL3084884 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL267562 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL302796 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL322179 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL110349 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL108637 | — | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL324896 | — | Ki | = | 2420.0 | nM | 5.62 |
| CHEMBL110435 | — | Ki | = | 2520.0 | nM | 5.60 |
| CHEMBL110120 | — | Ki | = | 4010.0 | nM | 5.40 |
| CHEMBL310310 | — | Ki | = | 5380.0 | nM | 5.27 |
| CHEMBL108495 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL110247 | — | Ki | > | 8000.0 | nM | - |
| CHEMBL109110 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL275707 | RIMCAZOLE | Ki | > | 8000.0 | nM | - |
| CHEMBL318770 | — | Ki | > | 8000.0 | nM | - |
| CHEMBL110754 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL110726 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL314726 | — | Ki | > | 8000.0 | nM | - |
| CHEMBL323220 | — | Ki | > | 8000.0 | nM | - |
| CHEMBL323184 | — | Ki | > | 8000.0 | nM | - |