Assay Detail
Binding
CHEMBL673447
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Binding affinity at human Dopamine receptor D3 (hD3) using [3H]spiperone radioligand.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.51 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135044 | — | — | 1 | 9.70 |
| CHEMBL135725 | — | — | 1 | 9.00 |
| CHEMBL423890 | — | — | 1 | 8.96 |
| CHEMBL134807 | — | — | 1 | 8.62 |
| CHEMBL135357 | — | — | 1 | 8.47 |
| CHEMBL135395 | — | — | 1 | 8.08 |
| CHEMBL134343 | — | — | 1 | 7.71 |
| CHEMBL138016 | — | — | 1 | 7.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135044 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL135725 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL423890 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL134807 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL135357 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL135395 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL134343 | — | Ki | = | 19.7 | nM | 7.71 |
| CHEMBL138016 | — | Ki | = | 27.6 | nM | 7.56 |