Assay Detail
Functional
CHEMBL673517
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The compound was evaluated for the growth inhibition of Dx5 cell lines using MTT assay.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of daunorubicin-paclitaxel dimers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.41 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411141 | MIXTURE OF DAUNORUBICIN AND PACLITAXEL | — | 1 | 6.00 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 5.70 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.57 |
| CHEMBL411204 | — | — | 1 | 5.00 |
| CHEMBL262831 | — | — | 1 | 4.80 |
| CHEMBL414996 | — | — | 1 | - |
| CHEMBL276722 | — | — | 1 | - |
| CHEMBL427812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411141 | MIXTURE OF DAUNORUBICIN AND PACLITAXEL | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL411204 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL262831 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL414996 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL276722 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL427812 | — | IC50 | > | 50000.0 | nM | - |