Assay Detail
Functional
CHEMBL673518
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The compound was evaluated for the growth inhibition of Dx5 w/PSC cell lines using MTT assay.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of daunorubicin-paclitaxel dimers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.35 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.52 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.85 |
| CHEMBL262831 | — | — | 1 | 7.44 |
| CHEMBL411204 | — | — | 1 | 6.00 |
| CHEMBL276722 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL262831 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL411204 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL276722 | — | IC50 | = | 1100.0 | nM | 5.96 |