Assay Detail
Binding
CHEMBL673639
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In vitro affinity against Dopamine receptor D4
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.59 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.20 |
| CHEMBL143027 | — | — | 1 | 7.68 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.42 |
| CHEMBL143022 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL143027 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL42 | CLOZAPINE | Ki | = | 38.02 | nM | 7.42 |
| CHEMBL143022 | — | Ki | = | 91.2 | nM | 7.04 |