Assay Detail
Functional
CHEMBL673642
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Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.84 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300956 | — | — | 1 | 8.92 |
| CHEMBL51023 | — | — | 1 | 8.47 |
| CHEMBL49502 | — | — | 1 | 8.28 |
| CHEMBL49231 | — | — | 1 | 8.08 |
| CHEMBL296953 | — | — | 1 | 8.08 |
| CHEMBL296506 | — | — | 1 | 7.89 |
| CHEMBL48819 | — | — | 1 | 7.82 |
| CHEMBL298166 | — | — | 1 | 7.80 |
| CHEMBL45244 | PD-168,077 | — | 1 | 7.77 |
| CHEMBL423659 | — | — | 1 | 7.62 |
| CHEMBL48807 | — | — | 1 | 7.51 |
| CHEMBL298763 | — | — | 1 | 6.97 |
| CHEMBL51536 | — | — | 1 | 6.66 |
| CHEMBL49876 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300956 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL51023 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL49502 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL49231 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL296953 | — | EC50 | = | 8.4 | nM | 8.08 |
| CHEMBL296506 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL48819 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL298166 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL45244 | PD-168,077 | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL423659 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL48807 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL298763 | — | EC50 | = | 106.0 | nM | 6.97 |
| CHEMBL51536 | — | EC50 | = | 218.0 | nM | 6.66 |
| CHEMBL49876 | — | EC50 | > | 3.9 | nM | - |