Assay Detail
Binding
CHEMBL673839
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In vitro binding affinity towards Dopamine receptor D3 by using [3H]spiperone as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.59 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2021538 | — | — | 1 | 7.82 |
| CHEMBL2021525 | — | — | 1 | 6.92 |
| CHEMBL26998 | — | — | 1 | 6.75 |
| CHEMBL28437 | — | — | 1 | 6.56 |
| CHEMBL554220 | — | — | 1 | 6.45 |
| CHEMBL2021539 | — | — | 1 | 6.28 |
| CHEMBL28313 | — | — | 1 | 6.16 |
| CHEMBL2021524 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2021538 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2021525 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL26998 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL28437 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL554220 | — | Ki | = | 359.0 | nM | 6.45 |
| CHEMBL2021539 | — | Ki | = | 524.0 | nM | 6.28 |
| CHEMBL28313 | — | Ki | = | 691.0 | nM | 6.16 |
| CHEMBL2021524 | — | Ki | = | 1570.0 | nM | 5.80 |