Assay Detail
Functional
CHEMBL673904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of VEGF-stimulated mitogenesis as determined in human umbilical vein endothelial cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.60 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324489 | — | — | 1 | 8.40 |
| CHEMBL117052 | — | — | 1 | 8.40 |
| CHEMBL119552 | — | — | 1 | 8.40 |
| CHEMBL119276 | — | — | 1 | 8.40 |
| CHEMBL118569 | — | — | 1 | 8.10 |
| CHEMBL333297 | — | — | 1 | 7.77 |
| CHEMBL323838 | — | — | 1 | 7.57 |
| CHEMBL118832 | — | — | 1 | 7.52 |
| CHEMBL117983 | — | — | 1 | 7.51 |
| CHEMBL118748 | — | — | 1 | 7.39 |
| CHEMBL325003 | — | — | 1 | 7.28 |
| CHEMBL420528 | — | — | 1 | 7.01 |
| CHEMBL221736 | — | — | 1 | 6.74 |
| CHEMBL118440 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324489 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL117052 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL119552 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL119276 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL118569 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL333297 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL323838 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL118832 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL117983 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL118748 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL325003 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL420528 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL221736 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL118440 | — | IC50 | = | 1140.0 | nM | 5.94 |