Assay Detail
Binding
CHEMBL673953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ErbB-2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.26 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160846 | — | — | 1 | 7.85 |
| CHEMBL155761 | — | — | 1 | 7.85 |
| CHEMBL160303 | — | — | 1 | 7.55 |
| CHEMBL422347 | — | — | 1 | 7.32 |
| CHEMBL157084 | — | — | 1 | 6.70 |
| CHEMBL269620 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160846 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL155761 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL160303 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL422347 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL157084 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL269620 | — | IC50 | = | 550.0 | nM | 6.26 |