Assay Detail
Binding
CHEMBL673956
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ERBB2 receptor autophosphorylation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.59 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56543 | — | — | 1 | 4.87 |
| CHEMBL293749 | — | — | 1 | 4.64 |
| CHEMBL53898 | — | — | 1 | 4.46 |
| CHEMBL56731 | — | — | 1 | 4.38 |
| CHEMBL440298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56543 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL293749 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL53898 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL56731 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL440298 | — | IC50 | > | 500000.0 | nM | - |