Assay Detail
Binding
CHEMBL674120
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Displacement of [3H]mazindol from dopamine transporter
10
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.54 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28394 | — | — | 2 | 9.44 |
| CHEMBL27336 | — | — | 1 | 8.46 |
| CHEMBL27586 | — | — | 1 | 8.04 |
| CHEMBL2115570 | — | — | 2 | 7.75 |
| CHEMBL285342 | — | — | 2 | 6.78 |
| CHEMBL120901 | — | — | 1 | 6.31 |
| CHEMBL28376 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28394 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL28394 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL27336 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL27586 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL2115570 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2115570 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL285342 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL120901 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL285342 | — | IC50 | = | 1105.0 | nM | 5.96 |
| CHEMBL28376 | — | IC50 | = | 1190.0 | nM | 5.92 |