Assay Detail
Binding
CHEMBL674276
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Binding affinity, displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel 2,5-disubstituted-1H-pyrroles with high affinity for the dopamine D3 receptor: N-benzyl modifications
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.49 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112705 | — | — | 1 | 9.70 |
| CHEMBL112735 | — | — | 1 | 9.60 |
| CHEMBL21967 | — | — | 1 | 9.50 |
| CHEMBL322070 | — | — | 1 | 9.40 |
| CHEMBL113229 | — | — | 1 | 9.20 |
| CHEMBL112219 | — | — | 1 | 9.10 |
| CHEMBL109532 | — | — | 1 | 9.10 |
| CHEMBL323817 | — | — | 1 | 9.10 |
| CHEMBL22156 | — | — | 1 | 8.90 |
| CHEMBL325859 | — | — | 1 | 8.80 |
| CHEMBL112268 | — | — | 1 | 8.80 |
| CHEMBL321244 | — | — | 1 | 8.60 |
| CHEMBL332270 | — | — | 1 | 8.60 |
| CHEMBL113523 | — | — | 1 | 8.50 |
| CHEMBL113524 | — | — | 1 | 8.30 |
| CHEMBL113606 | — | — | 1 | 8.20 |
| CHEMBL112505 | — | — | 1 | 8.10 |
| CHEMBL326662 | — | — | 1 | 8.00 |
| CHEMBL110793 | — | — | 1 | 8.00 |
| CHEMBL111884 | — | — | 1 | 8.00 |
| CHEMBL324044 | — | — | 1 | 7.90 |
| CHEMBL419760 | — | — | 1 | 7.50 |
| CHEMBL325658 | — | — | 1 | 7.30 |
| CHEMBL2367896 | — | — | 1 | 7.00 |
| CHEMBL325060 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112705 | — | Ki | = | 0.1995 | nM | 9.70 |
| CHEMBL112735 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL21967 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL322070 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL113229 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL112219 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL109532 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL323817 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL22156 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL325859 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL112268 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL321244 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL332270 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL113523 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL113524 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL113606 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL112505 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL326662 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL110793 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL111884 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL324044 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL419760 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL325658 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL2367896 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL325060 | — | Ki | = | 100.0 | nM | 7.00 |