Assay Detail
Binding
CHEMBL674342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cataleptogenic effect against cloned human Dopamine receptor D2 in male Sprague-Dawley rats in a bar test
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The acute EPS of haloperidol may be unrelated to its metabolic transformation to BCPP+.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.48 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210578 | — | — | 1 | 9.51 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.05 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210578 | — | Ki | = | 0.309 | nM | 9.51 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.8913 | nM | 9.05 |
| CHEMBL42 | CLOZAPINE | Ki | = | 134.9 | nM | 6.87 |