Assay Detail
Binding
CHEMBL674345
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Binding affinity against human Dopamine receptor D2 in mouse LtK- cells using [3H]spiperone.
24
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel 6-substituted 2-aminotetralins with potent and selective affinity for the dopamine D3 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.38 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278751 | — | — | 1 | 7.20 |
| CHEMBL424458 | — | — | 1 | 7.00 |
| CHEMBL132724 | — | — | 1 | 6.90 |
| CHEMBL132769 | — | — | 1 | 6.90 |
| CHEMBL130843 | — | — | 1 | 6.70 |
| CHEMBL130678 | — | — | 1 | 6.70 |
| CHEMBL441089 | — | — | 1 | 6.60 |
| CHEMBL130101 | — | — | 1 | 6.60 |
| CHEMBL129997 | — | — | 2 | 6.50 |
| CHEMBL130304 | — | — | 1 | 6.50 |
| CHEMBL336971 | — | — | 1 | 6.50 |
| CHEMBL132789 | — | — | 1 | 6.40 |
| CHEMBL130665 | — | — | 1 | 6.40 |
| CHEMBL131556 | — | — | 1 | 6.30 |
| CHEMBL132574 | — | — | 1 | 6.20 |
| CHEMBL338496 | — | — | 1 | 6.20 |
| CHEMBL334529 | — | — | 1 | 6.20 |
| CHEMBL133519 | — | — | 1 | 6.10 |
| CHEMBL130282 | — | — | 1 | 6.10 |
| CHEMBL133166 | — | — | 1 | 6.10 |
| CHEMBL133800 | — | — | 1 | 6.00 |
| CHEMBL130423 | — | — | 1 | 6.00 |
| CHEMBL338938 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278751 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL424458 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL132724 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL132769 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL130843 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL130678 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL441089 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL130101 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL336971 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL130304 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL129997 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL132789 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL130665 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL131556 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL132574 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL338496 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL334529 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL133519 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL130282 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL133166 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL130423 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL133800 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL129997 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL338938 | — | Ki | = | 6309.57 | nM | 5.20 |