Assay Detail
Binding
CHEMBL674347
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Binding affinity towards human Dopamine receptor D2 expressed in CHO cells by [125I]iodosulpiride displacement.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel 2,5-disubstituted-1H-pyrroles with high affinity for the dopamine D3 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.23 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21967 | — | — | 1 | 9.10 |
| CHEMBL277945 | SULTOPRIDE | 2.0 | 1 | 8.20 |
| CHEMBL280177 | — | — | 1 | 8.10 |
| CHEMBL20763 | — | — | 1 | 8.10 |
| CHEMBL281177 | — | — | 1 | 7.90 |
| CHEMBL280961 | — | — | 1 | 7.80 |
| CHEMBL277631 | — | — | 1 | 7.60 |
| CHEMBL22156 | — | — | 1 | 7.40 |
| CHEMBL22022 | — | — | 1 | 7.10 |
| CHEMBL21118 | — | — | 1 | 6.80 |
| CHEMBL279039 | — | — | 1 | 6.80 |
| CHEMBL21280 | — | — | 1 | 6.60 |
| CHEMBL20395 | — | — | 1 | 6.50 |
| CHEMBL20785 | — | — | 1 | 6.50 |
| CHEMBL277684 | — | — | 1 | 6.50 |
| CHEMBL282287 | — | — | 1 | 6.40 |
| CHEMBL20407 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21967 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL277945 | SULTOPRIDE | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL280177 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL20763 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL281177 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL280961 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL277631 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL22156 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL22022 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL21118 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL279039 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL21280 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL20395 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL20785 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL277684 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL282287 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL20407 | — | Ki | = | 3162.28 | nM | 5.50 |