Assay Detail
Binding
CHEMBL674412
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Affinity towards human Dopamine receptor D3 expressed in CHO cells using [3H]spiperone
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.21 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314952 | — | — | 1 | 8.27 |
| CHEMBL88289 | — | — | 1 | 7.83 |
| CHEMBL88365 | — | — | 1 | 7.54 |
| CHEMBL328051 | — | — | 1 | 7.45 |
| CHEMBL315864 | — | — | 1 | 7.25 |
| CHEMBL90476 | — | — | 1 | 7.25 |
| CHEMBL311539 | — | — | 1 | 7.02 |
| CHEMBL330108 | — | — | 1 | 6.23 |
| CHEMBL88837 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314952 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL88289 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL88365 | — | Ki | = | 28.9 | nM | 7.54 |
| CHEMBL328051 | — | Ki | = | 35.4 | nM | 7.45 |
| CHEMBL315864 | — | Ki | = | 56.5 | nM | 7.25 |
| CHEMBL90476 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL311539 | — | Ki | = | 95.3 | nM | 7.02 |
| CHEMBL330108 | — | Ki | = | 591.3 | nM | 6.23 |
| CHEMBL88837 | — | Ki | = | 870.5 | nM | 6.06 |