Assay Detail
Binding
CHEMBL674492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]spiperone radioligand from cloned human Dopamine receptor D4 in CHO cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.75 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7927 | FAUC 113 | — | 1 | 8.51 |
| CHEMBL57176 | — | — | 1 | 8.23 |
| CHEMBL60815 | — | — | 1 | 7.92 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.80 |
| CHEMBL2113718 | — | — | 1 | 7.75 |
| CHEMBL56118 | — | — | 1 | 7.68 |
| CHEMBL58662 | — | — | 1 | 7.08 |
| CHEMBL294394 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7927 | FAUC 113 | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL57176 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL60815 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL42 | CLOZAPINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2113718 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL56118 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL58662 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL294394 | — | Ki | = | 100.0 | nM | 7.00 |