Assay Detail
Binding
CHEMBL674497
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Displacement of [3H]spiperone from human Dopamine receptor D4 expressed in HEK293 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.21 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61079 | — | — | 1 | 8.92 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.64 |
| CHEMBL293341 | — | — | 1 | 8.60 |
| CHEMBL444309 | — | — | 1 | 8.46 |
| CHEMBL61195 | — | — | 1 | 8.44 |
| CHEMBL6416 | — | — | 1 | 8.26 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.00 |
| CHEMBL58296 | — | — | 1 | 7.36 |
| CHEMBL61080 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61079 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL293341 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL444309 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL61195 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL6416 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL42 | CLOZAPINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL58296 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL61080 | — | Ki | = | 61.0 | nM | 7.21 |