Assay Detail
Binding
CHEMBL674498
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Displacement of [3H]spiperone from human Dopamine receptor D4 expressed in HEK293 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.95 | 9.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279247 | — | — | 1 | 9.41 |
| CHEMBL26120 | — | — | 1 | 8.92 |
| CHEMBL25772 | — | — | 1 | 8.60 |
| CHEMBL287412 | — | — | 1 | 8.51 |
| CHEMBL24051 | — | — | 1 | 8.51 |
| CHEMBL281195 | — | — | 1 | 8.33 |
| CHEMBL24052 | — | — | 1 | 8.28 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.00 |
| CHEMBL25938 | — | — | 1 | 7.96 |
| CHEMBL23537 | — | — | 1 | 7.82 |
| CHEMBL284346 | — | — | 1 | 7.77 |
| CHEMBL25887 | — | — | 1 | 7.75 |
| CHEMBL24539 | — | — | 1 | 7.57 |
| CHEMBL24170 | — | — | 1 | 7.50 |
| CHEMBL287217 | — | — | 1 | 7.40 |
| CHEMBL24809 | — | — | 1 | 6.85 |
| CHEMBL24603 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279247 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL26120 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL25772 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL287412 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL24051 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL281195 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL24052 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL42 | CLOZAPINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL25938 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL23537 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL284346 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL25887 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL24539 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL24170 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL287217 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL24809 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL24603 | — | Ki | = | 1200.0 | nM | 5.92 |