Assay Detail
Binding
CHEMBL674500
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Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D4 in COS7 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding of 5H-dibenzo[a,d]cycloheptene and dibenz[b,f]oxepin analogues of clozapine to dopamine and serotonin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.71 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90882 | — | — | 1 | 9.27 |
| CHEMBL89970 | — | — | 1 | 8.70 |
| CHEMBL831 | LOXAPINE | 4.0 | 1 | 8.31 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.15 |
| CHEMBL539057 | — | — | 1 | 8.02 |
| CHEMBL432762 | — | — | 1 | 7.92 |
| CHEMBL554670 | — | — | 1 | 7.92 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.68 |
| CHEMBL556969 | — | — | 1 | 7.58 |
| CHEMBL542029 | — | — | 1 | 7.55 |
| CHEMBL163863 | — | — | 1 | 7.54 |
| CHEMBL544418 | — | — | 1 | 7.43 |
| CHEMBL555362 | — | — | 1 | 7.22 |
| CHEMBL163239 | — | — | 1 | 7.00 |
| CHEMBL94067 | — | — | 1 | 6.57 |
| CHEMBL544184 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90882 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL89970 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL831 | LOXAPINE | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL85 | RISPERIDONE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL539057 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL432762 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL554670 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL42 | CLOZAPINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL556969 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL542029 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL163863 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL544418 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL555362 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL163239 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL94067 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL544184 | — | Ki | = | 320.0 | nM | 6.50 |