Assay Detail
Binding
CHEMBL674590
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Binding affinity for dopamine receptor D3 expressed in Sf9 cells using [125I]IABN the radioligand.
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 8.02 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54866 | — | — | 1 | 10.40 |
| CHEMBL52588 | — | — | 1 | 10.40 |
| CHEMBL54667 | — | — | 1 | 9.70 |
| CHEMBL52298 | — | — | 1 | 9.40 |
| CHEMBL54865 | — | — | 1 | 9.10 |
| CHEMBL50465 | — | — | 1 | 9.00 |
| CHEMBL51959 | — | — | 1 | 8.96 |
| CHEMBL53102 | — | — | 1 | 8.85 |
| CHEMBL298875 | — | — | 1 | 8.80 |
| CHEMBL298759 | — | — | 1 | 8.72 |
| CHEMBL52300 | — | — | 1 | 8.62 |
| CHEMBL53778 | — | — | 1 | 8.60 |
| CHEMBL301929 | — | — | 1 | 8.59 |
| CHEMBL53320 | — | — | 1 | 8.54 |
| CHEMBL53038 | — | — | 1 | 8.49 |
| CHEMBL54026 | — | — | 1 | 8.24 |
| CHEMBL54662 | — | — | 1 | 8.12 |
| CHEMBL416846 | — | — | 1 | 7.92 |
| CHEMBL51754 | — | — | 1 | 7.89 |
| CHEMBL301302 | — | — | 1 | 7.88 |
| CHEMBL53650 | — | — | 1 | 7.84 |
| CHEMBL416481 | — | — | 1 | 7.52 |
| CHEMBL298864 | — | — | 1 | 7.39 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.33 |
| CHEMBL423122 | — | — | 1 | 7.32 |
| CHEMBL301732 | — | — | 1 | 7.30 |
| CHEMBL54571 | — | — | 1 | 7.28 |
| CHEMBL53078 | — | — | 1 | 7.24 |
| CHEMBL53218 | — | — | 1 | 7.17 |
| CHEMBL54027 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54866 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL52588 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL54667 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL52298 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL54865 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL50465 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL51959 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL53102 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL298875 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL298759 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL52300 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL53778 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL301929 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL53320 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL53038 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL54026 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL54662 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL416846 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL51754 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL301302 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL53650 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL416481 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL298864 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL423122 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL301732 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL54571 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL53078 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL53218 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL54027 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL50517 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL50352 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL52835 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL51856 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL54092 | — | Ki | = | 899.0 | nM | 6.05 |
| CHEMBL53401 | — | Ki | = | 1431.0 | nM | 5.84 |