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Assay Detail

CHEMBL674591

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at dopamine receptor D3 on Sf9 cells by [125I]IABN displacement.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type Sf9
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(3) dopamine receptor (CHEMBL3138)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.
Mach RH, Huang Y, Freeman RA, Wu L, Vangveravong S, Luedtke RR.
Bioorg Med Chem Lett (2004) 14 : 195 -202
PubMed 14684327 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 7.76 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL62638 1 9.40
CHEMBL59725 1 9.30
CHEMBL305362 1 9.05
CHEMBL301242 1 8.85
CHEMBL300780 1 8.85
CHEMBL59713 1 8.68
CHEMBL53038 1 8.49
CHEMBL303796 1 8.42
CHEMBL60213 1 8.41
CHEMBL287198 1 8.10
CHEMBL61789 1 7.99
CHEMBL305366 1 7.75
CHEMBL64176 1 7.67
CHEMBL60133 1 7.09
CHEMBL60139 1 6.97
CHEMBL60140 1 6.90
CHEMBL64751 1 6.51
CHEMBL60048 1 6.50
CHEMBL64261 1 6.31
CHEMBL291439 1 6.20
CHEMBL64260 1 5.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL62638 Ki = 0.4 nM 9.40
CHEMBL59725 Ki = 0.5 nM 9.30
CHEMBL305362 Ki = 0.9 nM 9.05
CHEMBL301242 Ki = 1.4 nM 8.85
CHEMBL300780 Ki = 1.4 nM 8.85
CHEMBL59713 Ki = 2.1 nM 8.68
CHEMBL53038 Ki = 3.2 nM 8.49
CHEMBL303796 Ki = 3.8 nM 8.42
CHEMBL60213 Ki = 3.9 nM 8.41
CHEMBL287198 Ki = 8.0 nM 8.10
CHEMBL61789 Ki = 10.2 nM 7.99
CHEMBL305366 Ki = 17.8 nM 7.75
CHEMBL64176 Ki = 21.4 nM 7.67
CHEMBL60133 Ki = 81.6 nM 7.09
CHEMBL60139 Ki = 106.5 nM 6.97
CHEMBL60140 Ki = 126.5 nM 6.90
CHEMBL64751 Ki = 310.7 nM 6.51
CHEMBL60048 Ki = 313.0 nM 6.50
CHEMBL64261 Ki = 488.0 nM 6.31
CHEMBL291439 Ki = 627.0 nM 6.20
CHEMBL64260 Ki = 3760.0 nM 5.42