Assay Detail
Binding
CHEMBL674592
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Binding affinity for rat striatum Dopamine receptor D3 (sf9 cells) by [3H]7-OH-DPAT displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.32 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339960 | — | — | 1 | 9.74 |
| CHEMBL126889 | — | — | 1 | 9.42 |
| CHEMBL435218 | — | — | 1 | 9.39 |
| CHEMBL127400 | — | — | 1 | 9.31 |
| CHEMBL340641 | — | — | 1 | 9.18 |
| CHEMBL420510 | — | — | 1 | 9.06 |
| CHEMBL25236 | BP-897 | — | 1 | 9.04 |
| CHEMBL124444 | — | — | 1 | 8.80 |
| CHEMBL125916 | — | — | 1 | 8.54 |
| CHEMBL340126 | — | — | 1 | 8.37 |
| CHEMBL127317 | — | — | 1 | 8.32 |
| CHEMBL125193 | — | — | 1 | 8.11 |
| CHEMBL124744 | — | — | 1 | 8.04 |
| CHEMBL127344 | — | — | 1 | 7.96 |
| CHEMBL126590 | — | — | 1 | 7.55 |
| CHEMBL124713 | — | — | 1 | 7.38 |
| CHEMBL2112643 | — | — | 1 | 7.13 |
| CHEMBL123952 | — | — | 1 | 6.53 |
| CHEMBL341117 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339960 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL126889 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL435218 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL127400 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL340641 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL420510 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL25236 | BP-897 | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL124444 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL125916 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL340126 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL127317 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL125193 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL124744 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL127344 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL126590 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL124713 | — | Ki | = | 41.3 | nM | 7.38 |
| CHEMBL2112643 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL123952 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL341117 | — | Ki | = | 759.0 | nM | 6.12 |