Assay Detail
Binding
CHEMBL674594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against [3H]spiperone binding to Dopamine receptor D3 expressed in CHO-K1 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.04 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310607 | — | — | 1 | 7.46 |
| CHEMBL81675 | — | — | 1 | 7.28 |
| CHEMBL79812 | — | — | 1 | 7.21 |
| CHEMBL3706603 | — | — | 1 | 6.20 |
| CHEMBL82541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310607 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL81675 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL79812 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL3706603 | — | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL82541 | — | Ki | > | 2500.0 | nM | - |