Assay Detail
Binding
CHEMBL674596
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Binding affinity to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.91 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | 2.0 | 1 | 9.80 |
| CHEMBL319597 | — | — | 1 | 9.62 |
| CHEMBL329106 | — | — | 1 | 9.24 |
| CHEMBL92199 | — | — | 1 | 8.82 |
| CHEMBL92924 | — | — | 1 | 8.77 |
| CHEMBL327984 | — | — | 1 | 8.72 |
| CHEMBL94050 | — | — | 1 | 8.66 |
| CHEMBL96703 | — | — | 1 | 8.43 |
| CHEMBL96369 | — | — | 1 | 8.36 |
| CHEMBL92192 | — | — | 1 | 8.33 |
| CHEMBL330318 | — | — | 1 | 8.29 |
| CHEMBL93198 | — | — | 1 | 8.23 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.19 |
| CHEMBL93021 | — | — | 1 | 7.82 |
| CHEMBL328866 | — | — | 1 | 7.68 |
| CHEMBL91859 | — | — | 1 | 7.48 |
| CHEMBL315446 | — | — | 1 | 7.44 |
| CHEMBL92030 | — | — | 1 | 7.26 |
| CHEMBL319079 | — | — | 1 | 7.22 |
| CHEMBL316317 | — | — | 1 | 7.00 |
| CHEMBL94200 | — | — | 1 | 6.82 |
| CHEMBL95096 | — | — | 1 | 6.70 |
| CHEMBL91693 | — | — | 1 | 6.70 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.64 |
| CHEMBL96792 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL319597 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL329106 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL92199 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL92924 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL327984 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL94050 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL96703 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL96369 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL92192 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL330318 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL93198 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL93021 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL328866 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL91859 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL315446 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL92030 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL319079 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL316317 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL94200 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL95096 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL91693 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL42 | CLOZAPINE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL96792 | — | Ki | = | 3000.0 | nM | 5.52 |