Assay Detail
Functional
CHEMBL674744
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In vitro cellular toxicity against murine mammary carcinoma EMT6 cell line after 4 hr of compound exposure
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | EMT6 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.82 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302363 | — | — | 1 | 10.52 |
| CHEMBL66051 | — | — | 1 | 9.89 |
| CHEMBL432909 | — | — | 1 | 9.52 |
| CHEMBL307572 | — | — | 1 | 9.25 |
| CHEMBL70011 | — | — | 1 | 8.51 |
| CHEMBL307801 | — | — | 1 | 8.49 |
| CHEMBL69680 | — | — | 1 | 8.30 |
| CHEMBL69443 | — | — | 1 | 7.92 |
| CHEMBL279754 | DSB-120 | — | 1 | 7.64 |
| CHEMBL307542 | — | — | 1 | 7.29 |
| CHEMBL305208 | — | — | 1 | 6.55 |
| CHEMBL70019 | — | — | 1 | 6.52 |
| CHEMBL302819 | — | — | 1 | 6.08 |
| CHEMBL293096 | — | — | 1 | 5.96 |
| CHEMBL66736 | — | — | 1 | 4.92 |
| CHEMBL302536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302363 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL66051 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL432909 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL307572 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL70011 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL307801 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL69680 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL69443 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL279754 | DSB-120 | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL307542 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL305208 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL70019 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL302819 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL293096 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL66736 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL302536 | — | IC50 | = | 0.0078 | nM | - |