Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL674745

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested for growth inhibition against EMT6 tumor cell line(murine mammary carcinoma).
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type EMT6
Confidence 1 — Organism
Curated By Expert

Target

EMT6 (CHEMBL614294)
Type CELL-LINE
Organism Mus musculus

Publication

5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits.
Atwell GJ, Milbank JJ, Wilson WR, Hogg A, Denny WA.
J Med Chem (1999) 42 : 3400 -3411
PubMed 10464026 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 8.90 10.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL117142 1 10.05
CHEMBL37705 3 9.89
CHEMBL113847 1 9.64
CHEMBL325178 1 9.40
CHEMBL333848 1 9.20
CHEMBL419586 1 9.20
CHEMBL325876 1 9.08
CHEMBL325693 1 9.07
CHEMBL314487 1 9.01
CHEMBL116575 1 9.01
CHEMBL115450 1 8.92
CHEMBL324721 1 8.89
CHEMBL114587 1 8.72
CHEMBL419219 1 8.70
CHEMBL113953 1 8.31
CHEMBL114467 1 8.28
CHEMBL114001 1 8.23
CHEMBL326732 1 6.67

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL117142 IC50 = 0.089 nM 10.05
CHEMBL37705 IC50 = 0.13 nM 9.89
CHEMBL113847 IC50 = 0.23 nM 9.64
CHEMBL37705 IC50 = 0.27 nM 9.57
CHEMBL325178 IC50 = 0.4 nM 9.40
CHEMBL333848 IC50 = 0.63 nM 9.20
CHEMBL419586 IC50 = 0.63 nM 9.20
CHEMBL325876 IC50 = 0.83 nM 9.08
CHEMBL325693 IC50 = 0.86 nM 9.07
CHEMBL314487 IC50 = 0.98 nM 9.01
CHEMBL116575 IC50 = 0.98 nM 9.01
CHEMBL115450 IC50 = 1.2 nM 8.92
CHEMBL324721 IC50 = 1.3 nM 8.89
CHEMBL114587 IC50 = 1.9 nM 8.72
CHEMBL419219 IC50 = 2.0 nM 8.70
CHEMBL113953 IC50 = 4.9 nM 8.31
CHEMBL114467 IC50 = 5.2 nM 8.28
CHEMBL114001 IC50 = 5.9 nM 8.23
CHEMBL37705 IC50 = 7.0 nM 8.15
CHEMBL326732 IC50 = 212.0 nM 6.67