Assay Detail
Binding
CHEMBL674889
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Binding affinity for human leukocyte elastase
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 8.53 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320942 | — | — | 1 | 10.22 |
| CHEMBL110443 | — | — | 1 | 9.46 |
| CHEMBL106592 | — | — | 1 | 9.46 |
| CHEMBL108477 | — | — | 1 | 9.46 |
| CHEMBL302961 | — | — | 1 | 9.42 |
| CHEMBL111029 | — | — | 1 | 9.24 |
| CHEMBL108622 | — | — | 1 | 9.19 |
| CHEMBL323030 | — | — | 1 | 9.19 |
| CHEMBL107936 | — | — | 1 | 9.19 |
| CHEMBL110125 | — | — | 1 | 9.09 |
| CHEMBL304114 | — | — | 1 | 9.07 |
| CHEMBL110685 | — | — | 1 | 8.96 |
| CHEMBL55210 | — | — | 2 | 8.89 |
| CHEMBL417935 | — | — | 1 | 8.82 |
| CHEMBL323231 | — | — | 1 | 8.80 |
| CHEMBL110364 | — | — | 1 | 8.77 |
| CHEMBL2370419 | — | — | 1 | 8.72 |
| CHEMBL110174 | — | — | 1 | 8.64 |
| CHEMBL354883 | — | — | 1 | 8.59 |
| CHEMBL308415 | — | — | 1 | 8.52 |
| CHEMBL108873 | — | — | 1 | 8.51 |
| CHEMBL110400 | — | — | 1 | 8.47 |
| CHEMBL306877 | — | — | 1 | 8.42 |
| CHEMBL108504 | — | — | 1 | 8.39 |
| CHEMBL108783 | — | — | 1 | 8.33 |
| CHEMBL321817 | — | — | 1 | 8.24 |
| CHEMBL109949 | — | — | 1 | 8.19 |
| CHEMBL278682 | — | — | 1 | 8.10 |
| CHEMBL105981 | — | — | 1 | 8.05 |
| CHEMBL79463 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320942 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL110443 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL108477 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL106592 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL302961 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL111029 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL108622 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL323030 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL107936 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL110125 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL304114 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL110685 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL55210 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL417935 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL323231 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL110364 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL2370419 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL110174 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL354883 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL308415 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL108873 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL55210 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL110400 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL306877 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL108504 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL108783 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL321817 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL109949 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL278682 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL105981 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL79463 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL106107 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2370426 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2370427 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL110241 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL110344 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2370425 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL326695 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL107993 | — | Ki | = | 130.0 | nM | 6.89 |