Assay Detail
Binding
CHEMBL674890
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Ability to inhibit [125I]-ET-1 binding to human cloned ETB receptors expressed on CHO cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent and selective ET-A antagonists. 2. Discovery and evaluation of potent and water soluble N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.04 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627022 | — | — | 1 | 7.39 |
| CHEMBL112531 | — | — | 1 | 6.89 |
| CHEMBL175616 | BOSENTAN SODIUM | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627022 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL112531 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL175616 | BOSENTAN SODIUM | Ki | = | 140.0 | nM | 6.85 |