Assay Detail
Binding
CHEMBL674943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at Dopamine receptor D2 expressed in CHO cells by [125I]iodosulpiride displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Fused aminotetralins: novel antagonists with high selectivity for the dopamine D3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.38 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99198 | — | — | 1 | 7.60 |
| CHEMBL319116 | — | — | 1 | 7.20 |
| CHEMBL318925 | — | — | 1 | 6.60 |
| CHEMBL97856 | — | — | 1 | 6.50 |
| CHEMBL99876 | — | — | 1 | 6.50 |
| CHEMBL2111592 | — | — | 1 | 6.50 |
| CHEMBL317996 | — | — | 1 | 6.40 |
| CHEMBL2111591 | — | — | 1 | 6.30 |
| CHEMBL97107 | — | — | 1 | 6.30 |
| CHEMBL95759 | — | — | 1 | 6.30 |
| CHEMBL95743 | — | — | 1 | 6.30 |
| CHEMBL98452 | — | — | 1 | 6.30 |
| CHEMBL419706 | — | — | 1 | 6.20 |
| CHEMBL97118 | — | — | 1 | 6.20 |
| CHEMBL97149 | — | — | 1 | 6.10 |
| CHEMBL329702 | — | — | 1 | 6.00 |
| CHEMBL319355 | — | — | 1 | 5.90 |
| CHEMBL97440 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99198 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL319116 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL318925 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL97856 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL99876 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL2111592 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL317996 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL2111591 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL97107 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL95759 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL95743 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL98452 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL419706 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL97118 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL97149 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL329702 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL319355 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL97440 | — | Ki | = | 1995.26 | nM | 5.70 |