Assay Detail
Binding
CHEMBL674989
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Displacement of [3H]spiperone from human Dopamine receptor D3 expressed in HEK293 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.16 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279247 | — | — | 1 | 7.55 |
| CHEMBL287412 | — | — | 1 | 6.92 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.70 |
| CHEMBL26120 | — | — | 1 | 6.58 |
| CHEMBL25772 | — | — | 1 | 6.35 |
| CHEMBL281195 | — | — | 1 | 6.35 |
| CHEMBL287217 | — | — | 1 | 6.13 |
| CHEMBL24051 | — | — | 1 | 6.09 |
| CHEMBL23537 | — | — | 1 | 6.09 |
| CHEMBL24170 | — | — | 1 | 5.89 |
| CHEMBL25938 | — | — | 1 | 5.85 |
| CHEMBL24539 | — | — | 1 | 5.85 |
| CHEMBL25887 | — | — | 1 | 5.66 |
| CHEMBL284346 | — | — | 1 | 5.60 |
| CHEMBL24809 | — | — | 1 | 5.52 |
| CHEMBL24052 | — | — | 1 | 5.36 |
| CHEMBL24603 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279247 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL287412 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL42 | CLOZAPINE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL26120 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL25772 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL281195 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL287217 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL24051 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL23537 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL24170 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL25938 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL24539 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL25887 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL284346 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL24809 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL24052 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL24603 | — | Ki | > | 4400.0 | nM | - |