Assay Detail
Binding
CHEMBL674994
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Affinity to displace [3H]spiperone from cloned human Dopamine receptor D3 stably expressed in HEK393 cell lines
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK393 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.28 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91498 | — | — | 1 | 6.89 |
| CHEMBL91669 | — | — | 1 | 6.82 |
| CHEMBL93958 | — | — | 1 | 6.20 |
| CHEMBL92189 | — | — | 1 | 6.03 |
| CHEMBL91821 | — | — | 1 | 5.44 |
| CHEMBL327339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91498 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL91669 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL93958 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL92189 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL91821 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL327339 | — | Ki | > | 4200.0 | nM | - |