Assay Detail
Binding
CHEMBL675052
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Compound was measured for its ability to compete with [3H]spiperone binding to the human Dopamine receptor D3 transfected in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.61 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335570 | — | — | 1 | 8.96 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.43 |
| CHEMBL335545 | CI-1007 | — | 1 | 7.78 |
| CHEMBL433002 | — | — | 1 | 7.57 |
| CHEMBL445102 | — | — | 1 | 7.06 |
| CHEMBL276500 | — | — | 1 | 6.88 |
| CHEMBL107492 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335570 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL335545 | CI-1007 | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL433002 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL445102 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL276500 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL107492 | — | Ki | = | 249.0 | nM | 6.60 |