Assay Detail
Binding
CHEMBL675189
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Tested in vitro for the inhibition of [3H]spiperone binding to Dopamine receptor D4, expressed in cloned CHO cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.14 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278751 | — | — | 1 | 7.32 |
| CHEMBL433002 | — | — | 1 | 7.26 |
| CHEMBL285755 | — | — | 1 | 6.83 |
| CHEMBL328107 | — | — | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
| CHEMBL430332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278751 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL433002 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL285755 | — | Ki | = | 148.0 | nM | 6.83 |
| CHEMBL328107 | — | Ki | > | 4067.0 | nM | - |
| CHEMBL56 | 8-OH-DPAT | Ki | > | 1515.0 | nM | - |
| CHEMBL430332 | — | Ki | > | 4067.0 | nM | - |