Assay Detail
Binding
CHEMBL675192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for dopamine D4-like receptor labelled with [3H]YM-09151-2 in retina
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Retina |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.48 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2092872 | — | — | 1 | 8.40 |
| CHEMBL72630 | — | — | 1 | 8.00 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.82 |
| CHEMBL1788303 | — | — | 1 | 7.64 |
| CHEMBL45244 | PD-168,077 | — | 1 | 7.60 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 7.23 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 6.73 |
| CHEMBL7393 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2092872 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL72630 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL59 | DOPAMINE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1788303 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL45244 | PD-168,077 | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL7549 | PRECLAMOL | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL7393 | — | Ki | = | 397.0 | nM | 6.40 |